Home Health Osinbajo welcomes the COVID-19 research report on probable prevention, treatment of drugs

Osinbajo welcomes the COVID-19 research report on probable prevention, treatment of drugs

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Vice President Yemi Osinbajo, SAN, has welcomed efforts by a team of Nigerian professors and scientists investigating the effectiveness of, and roles that IVERMECTIN drug can play in the treatment of the Coronavirus disease.

The team which is composed of Nigerian scholars at home and abroad has also submitted their report on the usefulness of the drug to the World Organisation which has already appointed a Peer Review expert from the United Kingdom.

 

Speaking yesterday while being briefed on the report by a team of scientists led by Prof. Femi Babalola, the Principal investigator and Prof. Chris Bode, the Chief Medical Director of LUTH, the Vice President expressed excitement that Nigeria and Nigerians “are at the cutting edge of scientific research into the treatment.”

According to him “we have an opportunity here and I am so fascinated to hear this drug has been used in the treatment of River Blindness in this country.”

While commending the efforts of the team, Prof. Osinbajo added that with the report, Nigeria is at an advantage both in knowledge and availability of the drug, especially since IVERMECTIN has been found useful not only in the treatment of COVID-19 but also as a prophylactic medication.

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He disclosed that the Federal Government will explore further ways to support the research for the benefit of Nigerians and humanity generally while also advancing the effective funding of scientific research in the country.

Members of the group named IVERCOVID Research Group are the Principal Investigator, Prof. Femi Babalola, an Ophthalmologist and surgeon; the Chief Medical Director of LUTH, Prof. Chris Bode; the Chairman of the Medical Advisory Council at LUTH, Prof. Lanre Adeyemo; a US-based Clinical Pharmacologist, Prof. Adesuyi Ajayi; two project virologists: Prof. S.A Omilabu and Dr Olumuyiwa Salu; and also the Project Coordinator, Dr. Felix Alakaloko.

Both Prof. Babalola and the CMD, LUTH commended the Buhari Presidency for encouraging the research and thanked the Vice President for his personal role and support.

The report is titled “A randomised controlled trial for the repurposing of IVERMECTIN in the management of COVID-19,” and highlights  are discussed below:

This scientific study/research, carried out in the Lagos University Teaching Hospital (LUTH) was undertaken following the report of a 5000-fold reduction in viral load by Australian workers with in-vitro use of Ivermectin on COVID-19 in culture.

The PI has worked extensively with Ivermectin on the Onchocerciasis-River Blindness control program, through which many Nigerians have used Ivermectin.

FINDINGS

The study revealed that the mechanism of action of Ivermectin, include “Inhibiting viral entry into cells nucleus; and “Direct suppression of viral RNA load of SARS CoV 2.”, among others.

Ivermectin is orally absorbed with higher absorption as a solution better than tablets, and “The Mean Residence Time” (MRT) is 3.4 days, while the suggested frequency of dosing could be twice a week.

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According to the group’s alternative hypothesis, it notes that “Safe doses of Ivermectin are useful in the treatment of patients with virology proven Covid 19 disease, lowering the viral load, shortening time to negativity, and causing improvement in clinical parameters when compared with Lopinavir/Ritonavir/Placebo.

However, the Null hypothesis Ho: Safe doses of Ivermectin are not useful in the treatment of patients with virology proven Covid 19 disease, does not lower viral load, and does not shorten time to negativity, neither does it cause improvement in clinical parameters when compared to Lopinavir/Ritonavir/Placebo.

OVERALL RESULTS

The Study noted that the randomisation was effectively based on the distribution of age, sex and some clinical presentation at baselines such as cough and fever, adding that 63 cases were recruited in all.

The final results of the study carried out showed that the “Days-To-Negative (DTN) reduced by 3.8 days overall; while a few patients are negative by day two, 50 per cent are negative by day 5.”

The study indicated that Clinical trials of Ivermectin have been carried out in at least 21 countries worldwide, including Nigeria. It referenced the study on “Meta-analysis of clinical trials of Ivermectin to treat COVID-19 infection” by Dr Andrew Hill, Department of Pharmacology, University of Liverpool, UK

STUDY’S PROPOSAL

The group proposed the adoption of IVERMECTIN into the uniform treatment guidelines of COVID- 19 in Nigeria, noting that the “Ivermectin could be used potentially as prophylaxis pending the rollout of vaccination programmes or alongside it.”

It also proposed that the PROPHYLAXIS STUDY could be carried out “within Frontline healthcare workers and “Study between wards in a “hotspot” Local government (Lagos state or FCT)

However, the group emphasized that IVERMECTIN “is not meant to replace other COVID-19 measures such as social distancing, face masking and hygiene, or vaccinations.” It added that “It is possibly an additional tool which can be deployed to fight the pandemic.”

The group stated that it has since forwarded a report of our findings to NAFDAC.